2/28/2024 0 Comments Biofluid mechanicsThe topic of this position paper deals with correlation of clinical observations with the biomechanics of blood flow in other words, we explore the link between observations of hemodynamic phenomena and mechanisms that have a strong mechanical component in their causal chain with disease manifestations or pathophysiological indicators. Because of its physiological predominance and clinical importance, arterial cardiovascular fluid dynamics has become the mainstay of transport phenomena biomechanics. Although biofluid concepts apply to numerous systems in the human body, including the ocular, 28 lymphatic, 48 synovial, 79 cerebrospinal, 43 cochlear, 58 pulmonary, 5 nasal, 24, 80 and others, 64 the focus in this exposition is on the cardiovascular system. Transport phenomena in general and biological fluid mechanics in particular play an important role in better understanding of clinical and pathological observations and in developing new methods for diagnosis in connection with physiological and/or computational models. Further advances in integrative modeling, incorporating multiscale and multiphysics techniques are also discussed. The introduction of novel mechanical biomarkers in device design and optimization, and applications in the characterization of more specific and focal conditions such as aneurysms, are at the center of attention. This position paper presents an overview of current approaches and future developments along this theme that were discussed at the 5th International Biofluid Symposium and Workshop held at the California Institute of Technology in 2008. When combined with underlying physiological models, a powerful set of tools becomes available to address unmet clinical needs, predominantly in the direction of enhanced diagnosis, as well as assessment and prediction of treatment outcomes. Exploring the relationship between blood flow phenomena and pathophysiological observations is enhanced by continuing advances in the imaging modalities, measurement techniques, and capabilities of computational models. Biofluid mechanics is increasingly applied in support of diagnosis and decision-making for treatment of clinical pathologies.
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